Lions prepare for Wednesday testJohn Marquis and Nathan Tyson are also unlikely to be involved having played in Monday night's U21 Development Squad game away to Brighton & Hove Albion in which Marquis scored The Lions' goal in a 2-1 defeat.
On loan midfielder Richard Chaplow will, however, miss out as a result of an ankle injury picked up at St Andrews for which the club are currently awaiting scan results.
Andy Keogh, who missed Saturday's 1-1 draw with Birmingham City through illness, could play some part against Dave Jones' side who have won three of their last five League games and find themselves in 18th - two points behind The Lions.
The 23-year-old will be hopeful of playing some part against The Owls ahead of Saturday's FA Cup Semi-Final with Wigan Athletic as Kenny's men look to move eight points clear of the Championship drop zone.
James' knee injury, picked up in the March defeat to Leeds United, was less serious than first feared; the winger returning to full first team training last Friday.
Kenny Jackett's attacking options could be boosted by the return of James Henry for tonight's crucial Championship clash against Sheffield Wednesday at The Den (7.45pm).